Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates.

Ding, Haozhong; Altai, Mohamed; Rinne, Sara S; Vorobyeva, Anzhelika; Tolmachev, Vladimir; Gräslund, Torbjörn; Orlova, Anna.

Afiliação

Ding H; Department of Protein Science, KTH Royal Institute of Technology, Roslagstullsbacken 21, 114 17 Stockholm, Sweden.
Altai M; Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Rinne SS; Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
Vorobyeva A; Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Tolmachev V; Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Gräslund T; Department of Protein Science, KTH Royal Institute of Technology, Roslagstullsbacken 21, 114 17 Stockholm, Sweden.
Orlova A; Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden. Anna.orlova@ilk.uu.se.

Cancers (Basel) ; 11(8)2019 Aug 14.

Article em En | MEDLINE | ID: mdl-31416167