Prognostic value of frailty in elderly patients with acute coronary syndrome: a systematic review and meta-analysis.
BMC Geriatr
; 19(1): 222, 2019 08 15.
Article
em En
| MEDLINE
| ID: mdl-31416442
ABSTRACT
BACKGROUND:
Frailty is common and associated with poorer outcomes in the elderly, but its prognostic value in acute coronary syndromes (ACS) requires clarification. We thus undertook a systematic review and meta-analysis to evaluate the relationship between frailty and poor prognosis in patients with ACS.METHODS:
We systematically searched PubMed, Embase to find literatures which studied the prognostic value of frailty in elderly patients with ACS. Our main endpoints were the all-cause mortality, cardiovascular disease (CVD), major bleeding and readmissions. We pooled studies using random-effect generic inverse variance method, and conducted three pre-specified subgroup analyses.RESULTS:
Of 1216 identified studies, 15 studies were included in our analysis. Compared with the normal group, frailty (HR = 2.65; 95%CI 1.81-3.89, I2 = 60.2%) and pre-frailty (HR = 1.41; 95%CI 1.19-1.66, I2 = 0%) were characterized by a higher risk of mortality after adjustment. Frailty also was associated with increased risk of any-type CVD, major bleeding and hospital readmissions in elderly patients with ACS. The pooled effect sizes in frail patients were 1.54 (95%CI 1.32-1.79), 1.51 (95%CI 1.14-1.99) and 1.51 (95%CI 1.09-2.10).CONCLUSIONS:
Frailty provides quantifiable and significant prognostic value for mortality and adverse events in elderly ACS patients, helping doctors to appraise the comprehensive prognosis risk and to applicate appropriate management strategies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Idoso Fragilizado
/
Síndrome Coronariana Aguda
/
Fragilidade
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article