Correlation of apparent diffusion coefficient and intravoxel incoherent motion imaging parameters with Ki-67 expression in extrahepatic cholangiocarcinoma.
Magn Reson Imaging
; 63: 80-84, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31425800
ABSTRACT
PURPOSE:
To investigate the correlation of magnetic resonance imaging (MRI), apparent diffusion coefficient (ADC) and intravoxel incoherent motion imaging parameters with Ki-67 expression in cholangiocarcinoma.METHODS:
A total of 42 extrahepatic cholangiocarcinoma (EHCC) cases confirmed by surgical pathology were analyzed retrospectively. Subjects underwent MRI at 3.0â¯T and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) sequential scanning prior to surgery, and postoperative Ki-67 expression was recorded by immunohistochemistry (IHC). The patients were divided into 4 groups (I-IV) based on increasing Ki-67 expression from - to +++. ADC values and IVIM-DWI parameters were calculated, including true diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*). The comparison among groups was analyzed by univariate ANOVA (normal distribution) or Kruskal-Wallis H (non-normal distribution). Spearman correlation analysis was used to analyze the correlation of each parameter with Ki-67 expression. The diagnostic efficiency of each parameter was compared using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.RESULTS:
Except for D*, other values had statistically significant differences between groups (Pâ¯<â¯0.05). ADC, D and f values had negative correlations with Ki-67 expression (r values were -0.607, -0.795, -0.531, respectively, Pâ¯<â¯0.05). The AUCs were 0.701, 0.880, 0.623, respectively (Pâ¯<â¯0.0001).CONCLUSION:
IVIM-DWI technology can reflect the proliferative activity of EHCC cells to a certain extent, and has clinical value for predicting the degree of malignancy of a tumor.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
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Colangiocarcinoma
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Antígeno Ki-67
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Imagem de Difusão por Ressonância Magnética
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article