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Constituents from Nauclea latifolia with Anti-Haemophilus influenzae Type b Inhibitory Activities.
Kezetas Bankeu, Jean Jules; Kenou Kagho, Donald Ulrich; Fotsing Fongang, Yannick Stéphane; Kouipou Toghueo, Rufin Marie; Mba'ning, Brice Mittérant; Tchouya Feuya, Guy Raymond; Boyom Fekam, Fabrice; Tchouankeu, Jean Claude; Ngouela, Silvère Augustin; Sewald, Norbert; Lenta, Bruno Ndjakou; Ali, Muhammad Shaiq.
Afiliação
  • Kezetas Bankeu JJ; Department of Chemistry, Faculty of Science , The University of Bamenda , P.O. Box 39, Bambili , Cameroon.
  • Kenou Kagho DU; Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
  • Fotsing Fongang YS; Department of Chemistry, Higher Teacher Training College , University of Maroua , P.O. Box 55, Maroua , Cameroon.
  • Kouipou Toghueo RM; Department of Biochemistry, Faculty of Science , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
  • Mba'ning BM; Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
  • Tchouya Feuya GR; Department of Chemistry, Faculty of Science , Scientific and Technical University of Masuku , P.O. Box 943, Franceville , Gabon.
  • Boyom Fekam F; Department of Biochemistry, Faculty of Science , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
  • Tchouankeu JC; Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
  • Ngouela SA; Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
  • Sewald N; Department of Chemistry , Bielefeld University , P.O. Box 100131, 33501 Bielefeld , Germany.
  • Lenta BN; Department of Chemistry, Higher Teacher Training College , University of Yaoundé I , P.O. Box 47, Yaoundé , Cameroon.
  • Ali MS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
J Nat Prod ; 82(9): 2580-2585, 2019 09 27.
Article em En | MEDLINE | ID: mdl-31429278
ABSTRACT
Three previously undescribed indole alkaloids, named latifolianine A (1) and latifoliaindoles A and B (2 and 3), along with 10 known compounds (4-13), were isolated from the heartwood of Nauclea latifolia. Their structures were elucidated based on the analysis of their NMR and MS data. Latifolianine A (1) represents an unusual and unprecedented monoterpene indole alkaloid unit condensed with an ursane-type pentacyclic triterpenoid moiety. Plausible biogenetic routes toward latifolianine A (1) and latifoliaindoles A and B (2 and 3) were proposed. All the isolates were assessed in vitro for their inhibitory effects on Haemophilus influenzae. Naucleidinal (7) exhibited potent antibacterial activity (MIC value of 3.1 µg/mL) as compared to a reference drug, ciprofloxacin (MIC value of 1.6 µg/mL).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Haemophilus influenzae / Rubiaceae / Antibacterianos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Haemophilus influenzae / Rubiaceae / Antibacterianos Idioma: En Ano de publicação: 2019 Tipo de documento: Article