A case of Good's syndrome complicated by erythema multiforme.
BMJ Case Rep
; 12(8)2019 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-31434669
ABSTRACT
Good's syndrome (GS) is a rare, adult-onset combined B cell and T cell immunodeficiency with an associated thymoma. These patients have an increased risk of bacterial, fungal, viral and opportunistic infections. This report describes a 75-year-old female patient who presented with a full body rash and an anterior mediastinal mass. She underwent a biopsy of her rash and mass, which revealed erythema multiforme and WHO Type A thymoma, respectively. During her hospitalisation, she was also found to have oropharyngeal candidiasis, methicillin-susceptible Staphylococcus aureus bacteraemia and herpes simplex virus type 2 (HSV-2) skin lesions. Based on the number of infections and severity of her rash, an immunocompromised state was suspected. Immunological testing revealed a B cell and T cell deficiency as well as low serum immunoglobulins. This combination of hypogammaglobulinaemia and thymoma led to a diagnosis of GS. While there have been many case reports of GS, this is the first report of the immunodeficiency presenting with erythema multiforme.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
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Timoma
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Combinação Trimetoprima e Sulfametoxazol
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Eritema Multiforme
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Reabilitação Cardíaca
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Síndromes de Imunodeficiência
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Antibacterianos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article