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Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer.
Yu, Liang; Zhu, Ling-Juan; Wang, An-Hua; Qin, Yu; Zhang, Xue; Jia, Jing-Ming; Yao, Xin-Sheng.
Afiliação
  • Yu L; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Zhu LJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Wang AH; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, China.
  • Qin Y; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Zhang X; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Jia JM; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Yao XS; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Nat Prod Res ; 35(9): 1452-1458, 2021 May.
Article em En | MEDLINE | ID: mdl-31450985
ABSTRACT
Three new phenolic glycosides, intermedia A-C (1-3), one new acyclic alcohol glycoside, intermedia D (4), together with 3 known glycosides (5-7), were isolated from the dried roots of Paeonia intermedia C. A. Meyer. Their structures were established by means of extensive spectroscopic analysis (HRESIMS, NMR). Compound 1 have a rare benzo[1,5]dioxepine skeleton. The bioassay results showed that compound 3 exhibited inhibitory activity against proinflammatory cytokines nitric oxide (NO) secretion in LPS-activated RAW264.7 cells with an IC50 value of 85.76 ± 1.36 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raízes de Plantas / Paeonia / Glicosídeos / Anti-Inflamatórios Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raízes de Plantas / Paeonia / Glicosídeos / Anti-Inflamatórios Idioma: En Ano de publicação: 2021 Tipo de documento: Article