Deep Protein Methylation Profiling by Combined Chemical and Immunoaffinity Approaches Reveals Novel PRMT1 Targets.

Hartel, Nicolas G; Chew, Brandon; Qin, Jian; Xu, Jian; Graham, Nicholas A

Hartel, Nicolas G; Chew, Brandon; Qin, Jian; Xu, Jian; Graham, Nicholas A.

Afiliação

Hartel NG; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089.
Chew B; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089.
Qin J; Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90089; Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90089; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, Califo
Xu J; Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90089; Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90089; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, Califo
Graham NA; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089. Electronic address: nagraham@usc.edu.

Mol Cell Proteomics ; 18(11): 2149-2164, 2019 11.

Article em En | MEDLINE | ID: mdl-31451547

Assuntos

Arginina/análogos & derivados; Processamento de Proteína Pós-Traducional; Proteína-Arginina N-Metiltransferases/metabolismo; Proteoma/análise; Proteínas de Ligação a RNA/metabolismo; Proteínas Repressoras/metabolismo; Arginina/metabolismo; Cromatografia de Afinidade; Regulação da Expressão Gênica; Humanos; Metilação; Proteína-Arginina N-Metiltransferases/antagonistas & inibidores; Proteína-Arginina N-Metiltransferases/genética; RNA Interferente Pequeno/genética; Proteínas Repressoras/antagonistas & inibidores; Proteínas Repressoras/genética; Transdução de Sinais; Especificidade por Substrato

Palavras-chave

Post-translational modifications; affinity proteomics; arginine; immunoaffinity; label-free quantification; lysine; methylation; strong cation exchange; systems biology; tandem mass spectrometry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginina / Proteína-Arginina N-Metiltransferases / Proteínas Repressoras / Processamento de Proteína Pós-Traducional / Proteínas de Ligação a RNA / Proteoma Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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