Efficient genome-wide first-generation phenotypic screening system in mice using the <i>piggyBac</i> transposon.

Chang, Hao; Pan, Yukun; Landrette, Sean; Ding, Sheng; Yang, Dong; Liu, Lufang; Tian, Lei; Chai, Hongyan; Li, Peining; Li, Da-Ming; Xu, Tian

Efficient genome-wide first-generation phenotypic screening system in mice using the piggyBac transposon.

Chang, Hao; Pan, Yukun; Landrette, Sean; Ding, Sheng; Yang, Dong; Liu, Lufang; Tian, Lei; Chai, Hongyan; Li, Peining; Li, Da-Ming; Xu, Tian.

Afiliação

Chang H; Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536.
Pan Y; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536.
Landrette S; School of Life Sciences, Westlake Institute for Advanced Study, Westlake University, 310024 Hangzhou, China.
Ding S; Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536.
Yang D; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536.
Liu L; Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536.
Tian L; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536.
Chai H; Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536.
Li P; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536.
Li DM; Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536.
Xu T; School of Life Sciences, Westlake Institute for Advanced Study, Westlake University, 310024 Hangzhou, China.

Proc Natl Acad Sci U S A ; 116(37): 18507-18516, 2019 09 10.

Article em En | MEDLINE | ID: mdl-31451639

Assuntos

Mapeamento Cromossômico/métodos; Elementos de DNA Transponíveis/genética; Genoma; Técnicas de Genotipagem/métodos; Mutagênese Insercional/métodos; Animais; Animais Recém-Nascidos; Mapeamento Cromossômico/economia; Modelos Animais de Doenças; Embrião de Mamíferos; Estudos de Viabilidade; Feminino; Retardo do Crescimento Fetal/genética; Fibroblastos; Técnicas de Genotipagem/economia; Humanos; Masculino; Camundongos/genética; Camundongos Transgênicos; Mutagênese Insercional/economia; Mutação; Fenótipo; Cultura Primária de Células

Palavras-chave

genome-wide screen; growth retardation; piggyBac transposon; six1; six4

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos de DNA Transponíveis / Mutagênese Insercional / Mapeamento Cromossômico / Genoma / Técnicas de Genotipagem Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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