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Mitochondrial Proteins in the Development of Parkinson's Disease.
Zilocchi, Mara; Fasano, Mauro; Alberio, Tiziana.
Afiliação
  • Zilocchi M; Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, Canada.
  • Fasano M; Department of Science and High Technology, University of Insubria, Busto Arsizio, VA, Italy.
  • Alberio T; Department of Science and High Technology, University of Insubria, Busto Arsizio, VA, Italy. tiziana.alberio@uninsubria.it.
Adv Exp Med Biol ; 1158: 17-44, 2019.
Article em En | MEDLINE | ID: mdl-31452133
Parkinson's disease (PD) is a multifactorial disorder whose etiology is not completely understood. Strong evidences suggest that mitochondrial impairment and altered mitochondrial disposal play a key role in the development of this pathology. Here we show this association in both genetic and sporadic forms of the disease. Moreover, we describe the mitochondrial dysfunctions in toxin-induced models of PD, thus highlighting the importance of environmental factors in the onset of this pathology. In particular, we focus our attention on mitochondrial dynamics, mitochondrial biogenesis, and mitophagy and explain how their impairment could have a negative impact on dopaminergic neurons function and survival. Lastly, we aim at clarifying the important role played by proteomics in this field of research, proteomics being a global and unbiased approach suitable to unravel alterations of the molecular pathways in multifactorial diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Mitocondriais Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Mitocondriais Idioma: En Ano de publicação: 2019 Tipo de documento: Article