Dual inhibition of cannabinoid CB<sub>1</sub> receptor and inducible NOS attenuates obesity-induced chronic kidney disease.

Udi, Shiran; Hinden, Liad; Ahmad, Majdoleen; Drori, Adi; Iyer, Malliga R; Cinar, Resat; Herman-Edelstein, Michal; Tam, Joseph

Dual inhibition of cannabinoid CB₁ receptor and inducible NOS attenuates obesity-induced chronic kidney disease.

Udi, Shiran; Hinden, Liad; Ahmad, Majdoleen; Drori, Adi; Iyer, Malliga R; Cinar, Resat; Herman-Edelstein, Michal; Tam, Joseph.

Afiliação

Udi S; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hinden L; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ahmad M; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Drori A; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Iyer MR; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Cinar R; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Herman-Edelstein M; Department of Nephrology & Hypertension, Rabin Medical Center, Petah Tikva, Israel.
Tam J; Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

Br J Pharmacol ; 177(1): 110-127, 2020 01.

Article em En | MEDLINE | ID: mdl-31454063

Assuntos

Dieta Hiperlipídica/efeitos adversos; Óxido Nítrico Sintase Tipo II/antagonistas & inibidores; Obesidade/prevenção & controle; Receptor CB1 de Canabinoide/antagonistas & inibidores; Insuficiência Renal Crônica/prevenção & controle; Animais; Antagonistas de Receptores de Canabinoides/farmacologia; Antagonistas de Receptores de Canabinoides/uso terapêutico; Linhagem Celular Transformada; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Óxido Nítrico Sintase Tipo II/metabolismo; Obesidade/etiologia; Obesidade/metabolismo; Receptor CB1 de Canabinoide/metabolismo; Insuficiência Renal Crônica/etiologia; Insuficiência Renal Crônica/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor CB1 de Canabinoide / Insuficiência Renal Crônica / Óxido Nítrico Sintase Tipo II / Dieta Hiperlipídica / Obesidade Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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