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Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region.
Guo, Ling-Chuan; Yu, Shengbing; Wu, De; Huang, Jinxu; Liu, Tao; Xiao, Jianpeng; Huang, Weixiong; Gao, Yanhong; Li, Xing; Zeng, Weilin; Rutherford, Shannon; Ma, Wenjun; Zhang, Yonghui; Lin, Lifeng.
Afiliação
  • Guo LC; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Yu S; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Wu; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Huang J; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Liu T; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Xiao J; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; School of Public Health, Southern Medical University, Guangzhou 510515, China.
  • Huang W; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Gao Y; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Li X; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; School of Public Health, Southern Medical University, Guangzhou 510515, China.
  • Zeng W; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Rutherford S; School of Medicine, Griffith University, Brisbane, QLD 4111, Australia.
  • Ma W; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Zhang Y; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. Electronic address: zyh@cdcp.org.cn.
  • Lin L; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Environ Pollut ; 254(Pt B): 112925, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31454572
ABSTRACT
Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and new flame retardants (NFRs) are known thyroid hormone (TH) disruptors, but their disrupting mechanisms in humans are not completely understood. In this study, we aimed to explore the disrupting mechanisms of the aforementioned chemicals via examining TH-regulated proteins and gene expression in human serum. Adult participants from an e-waste dismantling (exposed group) and a control region (control group) in South China provided blood samples for the research. Some compounds of PCBs, PBDEs, and NFRs showed strong binding affinity to the thyroid-stimulating hormone (TSH), thyroglobulin, thyroxine-binding globulin (TBG), gene expression of TH receptor α (TRα) and ß, and iodothyronine deiodinase I (ID1). The highly exposed individuals had lower levels of TBG, TSH, and expression of TRα, but higher expression of ID1 than those of the control group. The disruption of TH-regulated proteins and gene expression suggested the exertion of different and, at times, even contradictory effects on TH disruption. However, no statistically significant difference was found in the TH levels between the exposed and the control group, implying that the TH disruption induced by these chemicals depends on the combined influence of multiple mechanisms. Gene expression appears to be an effective approach for investigations of TH disruption and the potential health effects.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Tireóideos / Bifenilos Policlorados / Éteres Difenil Halogenados / Resíduo Eletrônico / Retardadores de Chama Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Tireóideos / Bifenilos Policlorados / Éteres Difenil Halogenados / Resíduo Eletrônico / Retardadores de Chama Idioma: En Ano de publicação: 2019 Tipo de documento: Article