Cytotoxicity and Anti-inflammatory Properties of Apigenin-Derived Isolaxifolin.
J Nat Prod
; 82(9): 2451-2459, 2019 09 27.
Article
em En
| MEDLINE
| ID: mdl-31465218
ABSTRACT
The rare flavonoid isolaxifolin, a potent insecticide, has been touted as a potential grain-protecting agent. In order to assess any impact of this natural product on human health and to explore its various other biological properties, we have established a semisynthesis from the simpler but structurally related and more abundant natural product apigenin. The five-step reaction sequence has provided, for the first time, sufficient material for an in-depth evaluation of the cytotoxic properties of the title natural product. The impact of isolaxifolin on certain pro-inflammatory cytokines in murine macrophage RAW 264.7 cells has also been examined. Such studies have revealed that isolaxifolin displays no toxic effects toward normal cells while displaying greater cytotoxicities against certain cancer cell lines than its synthetic precursor apigenin. Furthermore, unlike apigenin, isolaxifolin only reduced NO, TNF-α, and IL-6 secretions in LPS-induced RAW 264.7 cells in a rather modest and dose-independent manner.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apigenina
/
Anti-Inflamatórios
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article