Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-&#954;B and AP-1 Pathways.

Jung, Young Yun; Shanmugam, Muthu K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Shair, Omar H M; Um, Jae-Young; Sethi, Gautam; Ahn, Kwang Seok

Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways.

Jung, Young Yun; Shanmugam, Muthu K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Shair, Omar H M; Um, Jae-Young; Sethi, Gautam; Ahn, Kwang Seok.

Afiliação

Jung YY; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Shanmugam MK; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Chinnathambi A; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Alharbi SA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Shair OHM; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Um JY; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore. phcgs@nus.edu.sg.
Ahn KS; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. ksahn@khu.ac.kr.

Molecules ; 24(17)2019 Aug 28.

Article em En | MEDLINE | ID: mdl-31466313

Assuntos

Benzilisoquinolinas/farmacologia; Leucemia Mielogênica Crônica BCR-ABL Positiva/metabolismo; Mieloma Múltiplo/metabolismo; Transdução de Sinais/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Quinase I-kappa B/metabolismo; Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico; Mieloma Múltiplo/tratamento farmacológico; NF-kappa B/metabolismo; Fosforilação/efeitos dos fármacos; Fator de Transcrição AP-1/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

AP-1; NF-κB; apoptosis; cancer; fangchinoline

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Transdução de Sinais / Benzilisoquinolinas / Mieloma Múltiplo Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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