Unique Aspects of rRNA Biogenesis in Trypanosomatids.
Trends Parasitol
; 35(10): 778-794, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31473096
ABSTRACT
Trypanosomatids are protozoan parasites that cycle between an insect and a mammalian host. The large-subunit rRNA of these organisms undergoes unique processing events absent in other eukaryotes. Recently, small nucleolar RNAs (snoRNAs) that mediate these specific cleavages were identified. Trypanosomatid rRNA is rich in RNA modifications such as 2'-O-methylation (Nm) and pseudouridylation (Ψ) that are also guided by these snoRNAs. A subset of these modifications is developmentally regulated and increased in the parasite form that propagates in the mammalian host. Such hypermodification contributes the temperature adaptation and hence infectivity during cycling of the parasite. rRNA processing and modification should be considered promising drug targets for fighting the diseases caused by these parasites.
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Base de dados:
MEDLINE
Assunto principal:
RNA de Protozoário
/
Trypanosomatina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article