Exercise attenuates myocardial fibrosis and increases angiogenesis-related molecules in the myocardium of aged rats.
Arch Physiol Biochem
; 128(1): 1-6, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-31475581
ABSTRACT
OBJECTIVES:
The present study aimed to investigate the effect of two different exercise training protocols on myocardial fibrosis and the expression of some growth factors in aged rats.METHOD:
Twenty-four male Wistar rats were randomly assigned to high-intensity interval training (HIIT) group, continuous exercise training (CET) group, and the control group. After 6 weeks of experiment, mRNA levels of fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), adropin proteins, and myocardial fibrosis were assessed.RESULTS:
HIIT and CET induced a significant increase in the FGF-2 and adropin and a decrease in the myocardial fibrosis in compared with the control group. HIIT induced a significant increase in the VEGF if compared with the control group. There was no significant difference between CET and control group.CONCLUSION:
Six weeks of HIIT and CET attenuated age-related myocardial fibrosis thereby an increase in angiogenesis-related molecules in cardiac and endothelial tissues.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Envelhecimento
/
Neovascularização Fisiológica
/
Miocárdio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article