Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis.

Gonzalez Cardona, Jaime; Smith, Matthew D; Wang, Jingya; Kirby, Leslie; Schott, Jason T; Davidson, Todd; Karnell, Jodi L; Whartenby, Katharine A; Calabresi, Peter A

Gonzalez Cardona, Jaime; Smith, Matthew D; Wang, Jingya; Kirby, Leslie; Schott, Jason T; Davidson, Todd; Karnell, Jodi L; Whartenby, Katharine A; Calabresi, Peter A.

Afiliação

Gonzalez Cardona J; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Smith MD; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Wang J; Early Respiratory, Inflammation and Autoimmunity, R&D Biopharmaceuticals, AstraZeneca, Gaithersburg, Maryland, United States of America.
Kirby L; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Schott JT; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Davidson T; Early Respiratory, Inflammation and Autoimmunity, R&D Biopharmaceuticals, AstraZeneca, Gaithersburg, Maryland, United States of America.
Karnell JL; Viela Bio, Gaithersburg, Maryland, United States of America.
Whartenby KA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Calabresi PA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.

PLoS One ; 14(9): e0221747, 2019.

Article em En | MEDLINE | ID: mdl-31490950

Assuntos

Diferenciação Celular/efeitos dos fármacos; Colesterol/biossíntese; Células Precursoras de Oligodendrócitos/citologia; Células Precursoras de Oligodendrócitos/efeitos dos fármacos; Fumarato de Quetiapina/farmacologia; Tri-Iodotironina/farmacologia; Animais; Sinergismo Farmacológico; Regulação da Expressão Gênica/efeitos dos fármacos; Proteína Básica da Mielina/metabolismo; Células Precursoras de Oligodendrócitos/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Sinvastatina/farmacologia; Triterpenos/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tri-Iodotironina / Diferenciação Celular / Colesterol / Fumarato de Quetiapina / Células Precursoras de Oligodendrócitos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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