Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions.
Neurobiol Aging
; 84: 225-234, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31500909
ABSTRACT
White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aß-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aß-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aß-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Peptídeos beta-Amiloides
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Doença de Alzheimer
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Substância Branca
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article