Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis.
J Cyst Fibros
; 19(2): 299-304, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31501052
ABSTRACT
BACKGROUND:
POL6014 is a novel, orally inhaled neutrophil elastase (NE) inhibitor in development for cystic fibrosis (CF).METHODS:
Two studies, one in healthy volunteers (HVs, doses 20 to 960â¯mg) and one in subjects with CF (doses 80 to 320â¯mg) were conducted to evaluate the safety, tolerability and pharmacokinetics (PK) of single ascending doses of inhaled POL6014 with a Pari eFlow® nebuliser. PK was evaluated over a period of 24â¯h. In addition, NE activity in CF sputum was measured.RESULTS:
After single doses, POL6014 was safe and well tolerated up to 480â¯mg in HVs and at all doses in subjects with CF. POL6014 showed a dose-linear PK profile in both populations with Cmax between 0.2 and 2.5⯵M in HVs and between 0.2 and 0.5⯵M in subjects with CF. Tmax was reached at approximately 2-3â¯h. Mean POL6014 levels in CF sputum rapidly reached 1000⯵M and were still above 10⯵M at 24â¯h. >1-log reduction of active NE was observed at 3â¯h after dosing.CONCLUSION:
Inhalation of POL6014 can safely lead to high concentrations within the lung and simultaneously low plasma concentrations, allowing for a clear inhibition of NE in the sputum of subjects with CF after single dosing. TRIAL REGISTRATION European Medicines Agency EudraCT-Nr. 2015-001618-83 and 2016-000493-38.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Escarro
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Elastase de Leucócito
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Fibrose Cística
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Compostos Macrocíclicos
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Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article