Prostate-Specific Antigen Levels During Testosterone Treatment of Hypogonadal Older Men: Data from a Controlled Trial.
J Clin Endocrinol Metab
; 104(12): 6238-6246, 2019 12 01.
Article
em En
| MEDLINE
| ID: mdl-31504596
ABSTRACT
CONTEXT Prostate-specific antigen (PSA) changes during testosterone treatment of older hypogonadal men have not been rigorously evaluated. DESIGN:
Double-blinded, placebo-controlled trial.SETTING:
Twelve US academic medical centers.PARTICIPANTS:
Seven hundred ninety hypogonadal men ≥65 years of age with average testosterone levels ≤275 ng/dL. Men at high risk for prostate cancer were excluded.INTERVENTIONS:
Testosterone or placebo gel for 12 months. MAINOUTCOMES:
Percentile changes in PSA during testosterone treatment of 12 months.RESULTS:
Testosterone treatment that increased testosterone levels from 232 ± 63 ng/dL to midnormal was associated with a small but substantially greater increase (P < 0.001) in PSA levels than placebo treatment. Serum PSA levels increased from 1.14 ± 0.86 ng/mL (mean ± SD) at baseline by 0.47 ± 1.1 ng/mL at 12 months in the testosterone group and from 1.25 ± 0.86 ng/mL by 0.06 ± 0.72 ng/mL in the placebo group. Five percent of men treated with testosterone had an increase ≥1.7 ng/mL and 2.5% of men had an increase of ≥3.4 ng/mL. A confirmed absolute PSA >4.0 ng/mL at 12 months was observed in 1.9% of men in the testosterone group and 0.3% in the placebo group. Four men were diagnosed with prostate cancer; two were Gleason 8.CONCLUSIONS:
When hypogonadal older men with normal baseline PSA are treated with testosterone, 5% had an increase in PSA ≥1.7 ng/mL, and 2.5% had an increase ≥3.4 ng/mL.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Testosterona
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Antígeno Prostático Específico
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Terapia de Reposição Hormonal
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Hipogonadismo
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article