Impact of CT-based brachytherapy in elderly patients with cervical cancer.
Brachytherapy
; 18(6): 771-779, 2019.
Article
em En
| MEDLINE
| ID: mdl-31506225
ABSTRACT
PURPOSE:
Three-dimensional image-guided brachytherapy (3D-IGBT) has become the standard therapy for patients with cervical cancer. However, in this population, the impact of 3D-IGBT in elderly individuals remains unknown. This study assessed the efficacy of 3D-IGBT for elderly patients with cervical cancer. METHODS AND MATERIALS We performed a retrospective chart review of 105 consecutive patients with cervical squamous cell carcinoma aged ≥70 years who received radiotherapy alone between January 2001 and September 2014. All patients were treated with external beam radiotherapy and high-dose-rate intracavitary brachytherapy. We assessed the treatment outcomes in all patients. We then compared outcomes between two groups patients treated by changing the Point A dose at brachytherapy (Group A, n = 71) and those treated with 3D-IGBT at least twice (Group B, n = 34).RESULTS:
The median followup period was 59 (range, 6-203) months; the median age was 77 years. The 5-year local control and cause-specific survival rates were 89% and 78%, respectively. The 5-year cumulative rates of late toxicities of the rectum and bladder of Grade ≥3 were 2.0% and 4.2%, respectively. No statistically significant differences were observed in the local control and cause-specific survival rates, or in the incidence of rectal toxicities between groups. The 3-year cumulative rates of urinary toxicity of Grade ≥1 were 20.4% and 6.9% in Group A and Group B, respectively (p = 0.035).CONCLUSION:
In elderly patients with cervical cancer, 3D-IGBT could be performed safely and effectively and contributed to decreasing urinary toxicity incidence rates.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radioterapia Assistida por Computador
/
Braquiterapia
/
Tomografia Computadorizada por Raios X
/
Neoplasias do Colo do Útero
/
Imageamento Tridimensional
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article