Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPK&#945; signaling pathway.

Ying, Lei; Li, Na; He, Zhengyue; Zeng, Xueqin; Nan, Yan; Chen, Jiantong; Miao, Peipei; Ying, Yunyun; Lin, Wei; Zhao, Xinyu; Lu, Lu; Chen, Mengke; Cen, Wei; Guo, Tonglin; Li, Xiaokun; Huang, Zhifeng; Wang, Yang

Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway.

Ying, Lei; Li, Na; He, Zhengyue; Zeng, Xueqin; Nan, Yan; Chen, Jiantong; Miao, Peipei; Ying, Yunyun; Lin, Wei; Zhao, Xinyu; Lu, Lu; Chen, Mengke; Cen, Wei; Guo, Tonglin; Li, Xiaokun; Huang, Zhifeng; Wang, Yang.

Afiliação

Ying L; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Li N; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
He Z; Department of Pathology, Wenzhou Central Hospital, 325035, Wenzhou, Zhejiang, China.
Zeng X; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Nan Y; Department of Pathology, Suining Central Hospital, 629000, Suining, Sichuan, China.
Chen J; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Miao P; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Ying Y; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Lin W; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Zhao X; Department of Pharmacy, the Second People's Hospital of Pingyang, 325035, Wenzhou, Zhejiang, China.
Lu L; Department of Pathophysiology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Chen M; The First Affiliated Hospital & School of the First Clinical Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Cen W; School of Pharmaceutical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Guo T; School of Pharmaceutical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Li X; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Huang Z; The First Affiliated Hospital & School of the First Clinical Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
Wang Y; The First Affiliated Hospital & School of the First Clinical Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.

Cell Death Dis ; 10(9): 665, 2019 09 11.

Article em En | MEDLINE | ID: mdl-31511499

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Aorta/efeitos dos fármacos; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/metabolismo; Angiopatias Diabéticas/tratamento farmacológico; Células Endoteliais/efeitos dos fármacos; Endotélio Vascular/efeitos dos fármacos; Fatores de Crescimento de Fibroblastos/uso terapêutico; Proteínas Quinases Ativadas por AMP/genética; Animais; Aorta/metabolismo; Aorta/fisiopatologia; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/genética; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Tipo 1/complicações; Diabetes Mellitus Tipo 2/complicações; Angiopatias Diabéticas/metabolismo; Angiopatias Diabéticas/fisiopatologia; Células Endoteliais/metabolismo; Células Endoteliais/patologia; Endotélio Vascular/metabolismo; Fatores de Crescimento de Fibroblastos/genética; Fatores de Crescimento de Fibroblastos/metabolismo; Fatores de Crescimento de Fibroblastos/farmacologia; Células Endoteliais da Veia Umbilical Humana; Humanos; Hiperglicemia/tratamento farmacológico; Hiperglicemia/metabolismo; Resistência à Insulina/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Óxido Nítrico Sintase Tipo III/química; Óxido Nítrico Sintase Tipo III/genética; Óxido Nítrico Sintase Tipo III/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/genética; Proteínas Recombinantes/farmacologia; Proteínas Recombinantes/uso terapêutico; Transdução de Sinais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta / Endotélio Vascular / Células Endoteliais / Angiopatias Diabéticas / Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina / Proteínas Quinases Ativadas por AMP / Fatores de Crescimento de Fibroblastos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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