ß-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK<sub>1/2</sub>-NF-&#954;B signal pathway in murine hearts.

Sun, Shu-Zhen; Cao, Hong; Yao, Na; Zhao, Ling-Ling; Zhu, Xiao-Fang; Ni, Er-An; Zhu, Qi; Zhu, Wei-Zhong

ß-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK_1/2-NF-κB signal pathway in murine hearts.

Sun, Shu-Zhen; Cao, Hong; Yao, Na; Zhao, Ling-Ling; Zhu, Xiao-Fang; Ni, Er-An; Zhu, Qi; Zhu, Wei-Zhong.

Afiliação

Sun SZ; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Cao H; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Yao N; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Zhao LL; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Zhu XF; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Ni EA; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Zhu Q; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China.
Zhu WZ; Cardiovascular laboratory, Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, China. Zhuwz@ntu.edu.cn.

Acta Pharmacol Sin ; 41(2): 198-207, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31515529

Assuntos

Arginina Vasopressina/farmacologia; Coração/fisiopatologia; Interleucina-6/metabolismo; beta-Arrestina 2/genética; Animais; Arginina Vasopressina/administração & dosagem; Relação Dose-Resposta a Droga; Fibroblastos/metabolismo; Técnicas de Silenciamento de Genes; Insuficiência Cardíaca/fisiopatologia; Masculino; Camundongos; Camundongos Knockout; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; NF-kappa B/metabolismo; Ratos; Ratos Sprague-Dawley; Receptores de Vasopressinas/metabolismo

Palavras-chave

ERK1/2; IL-6; adult rat cardiac fibroblasts; arginine vasopressin; myocardial inflammation; ß-Arrestin 2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginina Vasopressina / Interleucina-6 / Beta-Arrestina 2 / Coração Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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