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Palladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-Iodoazetidine: Synthesis of 3-Arylazetidines.
Liu, Zhenwei; Luan, Nannan; Shen, Linhua; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie.
Afiliação
  • Liu Z; The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
  • Luan N; The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
  • Shen L; The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
  • Li J; Tetranov Biopharm, LLC. and Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou , 450052 , People's Republic of China.
  • Zou D; The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
  • Wu Y; The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
  • Wu Y; Tetranov Biopharm, LLC. and Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou , 450052 , People's Republic of China.
J Org Chem ; 84(19): 12358-12365, 2019 10 04.
Article em En | MEDLINE | ID: mdl-31532668
ABSTRACT
The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical laboratories in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article