Antiosteoclastic bone resorption activity of osteoprotegerin via enhanced AKT/mTOR/ULK1-mediated autophagic pathway.

Zhao, Hongyan; Sun, Ziqiang; Ma, Yonggang; Song, Ruilong; Yuan, Yan; Bian, Jianchun; Gu, Jianhong; Liu, Zongping

Zhao, Hongyan; Sun, Ziqiang; Ma, Yonggang; Song, Ruilong; Yuan, Yan; Bian, Jianchun; Gu, Jianhong; Liu, Zongping.

Afiliação

Zhao H; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Sun Z; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
Ma Y; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Song R; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Yuan Y; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
Bian J; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Gu J; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Liu Z; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.

J Cell Physiol ; 235(3): 3002-3012, 2020 03.

Article em En | MEDLINE | ID: mdl-31535378

Assuntos

Autofagia/efeitos dos fármacos; Osteoclastos/efeitos dos fármacos; Osteoprotegerina/farmacologia; Proteínas Proto-Oncogênicas c-akt/efeitos dos fármacos; Animais; Autofagia/fisiologia; Proteína Homóloga à Proteína-1 Relacionada à Autofagia/efeitos dos fármacos; Proteína Homóloga à Proteína-1 Relacionada à Autofagia/metabolismo; Reabsorção Óssea/metabolismo; Fator Estimulador de Colônias de Macrófagos/efeitos dos fármacos; Fator Estimulador de Colônias de Macrófagos/metabolismo; Masculino; Camundongos Endogâmicos BALB C; Osteoclastos/metabolismo; Osteoprotegerina/metabolismo; Fosfatidilinositol 3-Quinases/efeitos dos fármacos; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ligante RANK/metabolismo

Palavras-chave

AKT/mTOR/ULK1 signaling pathway; autophagy; bone resorption; osteoclast; osteoprotegerin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Autofagia / Proteínas Proto-Oncogênicas c-akt / Osteoprotegerina Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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