May Monocyte/HDL Cholesterol Ratio (MHR) and Neutrophil/Lymphocyte Ratio (NLR) Be an Indicator of Inflammation and Oxidative Stress in Patients with Keratoconus?
Ocul Immunol Inflamm
; 28(4): 632-636, 2020 May 18.
Article
em En
| MEDLINE
| ID: mdl-31560568
ABSTRACT
OBJECTIVE:
To evaluate monocyte/high-density lipoprotein cholesterol ratio (MHR) and neutrophil/lymphocyte ratio (NLR) in patients with keratoconus (KC).METHODS:
Thirty-one patients with KC (group 1) and 31 healthy control subjects (group 2) were included in the study. All participants' ocular examination findings, clinical and laboratory parameters were obtained from file records and laboratory archives.RESULTS:
When group 1 was compared with group 2, MHR (13.7 ± 5.0 vs. 9.1 ± 3.7; p < .001) and NLR (2.3 ± 0.8 vs. 1.7 ± 0.6; p < .001) were statistically significantly higher in group 1. Optimal MHR cutoff value for KC was calculated as 10.2 with 77.4% sensitivity and 64.5% specificity, and optimal NLR cut-off value for KC was found as 1.9 with 71.4% sensitivity and 55% specificity.CONCLUSION:
MHR and NLR values recognized as indicators of oxidative stress and systemic inflammation were significantly higher in patients with KC compared to the control group.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos
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Monócitos
/
Estresse Oxidativo
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Inflamação
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Ceratocone
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HDL-Colesterol
/
Neutrófilos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article