Recombinant Human Interleukin-15 and Anti-PD-L1 Combination Therapy Expands a CXCR3+PD1-/low CD8 T-Cell Subset in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Chen, Ping; Chen, Hui; Moussa, Maha; Cheng, Jie; Li, Tong; Qin, Jing; Lifson, Jeffrey D; Sneller, Michael C; Krymskaya, Ludmila; Godin, Steven; Lane, H Clifford; Catalfamo, Marta

Chen, Ping; Chen, Hui; Moussa, Maha; Cheng, Jie; Li, Tong; Qin, Jing; Lifson, Jeffrey D; Sneller, Michael C; Krymskaya, Ludmila; Godin, Steven; Lane, H Clifford; Catalfamo, Marta.

Afiliação

Chen P; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Chen H; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Moussa M; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Cheng J; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Li T; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Qin J; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington District of Columbia, USA.
Lifson JD; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Sneller MC; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland, USA.
Krymskaya L; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Godin S; Clinical Support Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Lane HC; Smithers Avanza Toxicology Services, Gaithersburg, Maryland, USA.
Catalfamo M; CMRS/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

J Infect Dis ; 221(4): 523-533, 2020 02 03.

Article em En | MEDLINE | ID: mdl-31562760

Assuntos

Anticorpos Monoclonais Humanizados/farmacologia; Anticorpos Monoclonais Humanizados/uso terapêutico; Antígeno B7-H1/antagonistas & inibidores; Linfócitos T CD8-Positivos/imunologia; Interleucina-15/uso terapêutico; Receptor de Morte Celular Programada 1/metabolismo; Receptores CXCR3/metabolismo; Síndrome de Imunodeficiência Adquirida dos Símios/tratamento farmacológico; Vírus da Imunodeficiência Símia; Animais; Anticorpos Monoclonais Humanizados/efeitos adversos; Quimioterapia Combinada; Feminino; Humanos; Interleucina-15/efeitos adversos; Interleucina-15/genética; Macaca mulatta; Masculino; Proteínas Recombinantes/efeitos adversos; Proteínas Recombinantes/uso terapêutico; Síndrome de Imunodeficiência Adquirida dos Símios/imunologia; Síndrome de Imunodeficiência Adquirida dos Símios/virologia; Resultado do Tratamento; Carga Viral/efeitos dos fármacos

Palavras-chave

HIV/SIV infection; IL-15; anti-PD-L1; checkpoint inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia / Linfócitos T CD8-Positivos / Interleucina-15 / Receptores CXCR3 / Anticorpos Monoclonais Humanizados / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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