Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling.

Yuan, Mei; Meng, Xiao-Wen; Ma, Jiao; Liu, Hong; Song, Shao-Yong; Chen, Qing-Cai; Liu, Hua-Yue; Zhang, Juan; Song, Nan; Ji, Fu-Hai; Peng, Ke

Yuan, Mei; Meng, Xiao-Wen; Ma, Jiao; Liu, Hong; Song, Shao-Yong; Chen, Qing-Cai; Liu, Hua-Yue; Zhang, Juan; Song, Nan; Ji, Fu-Hai; Peng, Ke.

Afiliação

Yuan M; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Meng XW; Department of Anesthesiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215008, People's Republic of China.
Ma J; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Liu H; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Song SY; Department of Anesthesiology and Pain Medicine, University of California Davis Health System, Sacramento, CA 95817, USA.
Chen QC; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Liu HY; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Zhang J; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Song N; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Ji FH; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.
Peng K; Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's Republic of China.

Drug Des Devel Ther ; 13: 3137-3149, 2019.

Article em En | MEDLINE | ID: mdl-31564830

Assuntos

Agonistas de Receptores Adrenérgicos alfa 2/farmacologia; Apoptose/efeitos dos fármacos; Cálcio/metabolismo; Dexmedetomidina/farmacologia; Miócitos Cardíacos/efeitos dos fármacos; Oxigênio/metabolismo; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Proteínas de Ligação a Tacrolimo/antagonistas & inibidores; Cálcio/administração & dosagem; Cálcio/análise; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Relação Dose-Resposta a Droga; Glucose/metabolismo; Humanos; Miócitos Cardíacos/metabolismo; Canal de Liberação de Cálcio do Receptor de Rianodina/genética; Transdução de Sinais/efeitos dos fármacos; Relação Estrutura-Atividade; Proteínas de Ligação a Tacrolimo/genética; Proteínas de Ligação a Tacrolimo/metabolismo

Palavras-chave

H9c2 cardiomyocytes; apoptosis; dexmedetomidine; intracellular calcium overload, FKBP12.6/RyR2; oxygen-glucose deprivation/reoxygenation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Cálcio / Apoptose / Canal de Liberação de Cálcio do Receptor de Rianodina / Dexmedetomidina / Proteínas de Ligação a Tacrolimo / Miócitos Cardíacos / Agonistas de Receptores Adrenérgicos alfa 2 Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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