BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia.
Onco Targets Ther
; 12: 7123-7127, 2019.
Article
em En
| MEDLINE
| ID: mdl-31564896
ABSTRACT
Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR mutation and TLS-ERG fusion gene in patient's bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR mutation or TLS-ERG fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance.
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MEDLINE
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En
Ano de publicação:
2019
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Article