Enhanced Solubility and Anticancer Potential of Mansonone G By ß-Cyclodextrin-Based Host-Guest Complexation: A Computational and Experimental Study.

Mahalapbutr, Panupong; Wonganan, Piyanuch; Charoenwongpaiboon, Thanapon; Prousoontorn, Manchumas; Chavasiri, Warinthorn; Rungrotmongkol, Thanyada

Mahalapbutr, Panupong; Wonganan, Piyanuch; Charoenwongpaiboon, Thanapon; Prousoontorn, Manchumas; Chavasiri, Warinthorn; Rungrotmongkol, Thanyada.

Afiliação

Mahalapbutr P; Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. p.mahalapbutr@gmail.com.
Wonganan P; Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. piyanuch.w@chula.ac.th.
Charoenwongpaiboon T; Starch and Cyclodextrin Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. thanapon.charoenwongpaiboon@gmail.com.
Prousoontorn M; Starch and Cyclodextrin Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. manchumas.h@chula.ac.th.
Chavasiri W; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. warinthorn.c@chula.ac.th.
Rungrotmongkol T; Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. t.rungrotmongkol@gmail.com.

Biomolecules ; 9(10)2019 09 27.

Article em En | MEDLINE | ID: mdl-31569832

Assuntos

Antineoplásicos/farmacologia; Simulação de Dinâmica Molecular; Naftoquinonas/farmacologia; Termodinâmica; beta-Ciclodextrinas/farmacologia; Células A549; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Naftoquinonas/química; Solubilidade; Células Tumorais Cultivadas; beta-Ciclodextrinas/química

Palavras-chave

beta-cyclodextrins; inclusion complex; lung cancer; mansonone G; molecular dynamics simulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Termodinâmica / Naftoquinonas / Beta-Ciclodextrinas / Simulação de Dinâmica Molecular / Antineoplásicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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