ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease.

Zhang, Qian; Hu, Changpeng; Huang, Jingbin; Liu, Wuyi; Lai, Wenjing; Leng, Faning; Tang, Qin; Liu, Yali; Wang, Qing; Zhou, Min; Sheng, Fangfang; Li, Guobing; Zhang, Rong

Zhang, Qian; Hu, Changpeng; Huang, Jingbin; Liu, Wuyi; Lai, Wenjing; Leng, Faning; Tang, Qin; Liu, Yali; Wang, Qing; Zhou, Min; Sheng, Fangfang; Li, Guobing; Zhang, Rong.

Afiliação

Zhang Q; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Hu C; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Huang J; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Liu W; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Lai W; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Leng F; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Tang Q; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Liu Y; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Wang Q; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Zhou M; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Sheng F; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China.
Li G; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China. rgwlsb@126.com.
Zhang R; Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 400037, Chongqing, China. xqpharmacylab@126.com.

Exp Mol Med ; 51(10): 1-13, 2019 10 02.

Article em En | MEDLINE | ID: mdl-31578315

Assuntos

Dopamina/deficiência; Neurônios Dopaminérgicos/metabolismo; Dinaminas/genética; Doença de Parkinson Secundária/genética; Quinases Associadas a rho/genética; 1-Metil-4-fenilpiridínio/administração & dosagem; Amidas/farmacologia; Animais; Apoptose/efeitos dos fármacos; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/patologia; Dinaminas/antagonistas & inibidores; Dinaminas/metabolismo; Regulação da Expressão Gênica; Humanos; Masculino; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitocôndrias/patologia; Dinâmica Mitocondrial/efeitos dos fármacos; Estresse Oxidativo; Células PC12; Doença de Parkinson Secundária/induzido quimicamente; Doença de Parkinson Secundária/tratamento farmacológico; Doença de Parkinson Secundária/patologia; Piridinas/farmacologia; Ratos; Transdução de Sinais; Substância Negra/efeitos dos fármacos; Substância Negra/metabolismo; Substância Negra/patologia; Quinases Associadas a rho/deficiência

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Secundária / Dopamina / Dinaminas / Quinases Associadas a rho / Neurônios Dopaminérgicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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