ß-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study.
Arch Physiol Biochem
; 128(1): 148-162, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-31583906
ABSTRACT
Beta-caryophyllene (BCP), are natural bicyclic sesquiterpenes which are present in numerous plants worldwide. BCP has antioxidant, antimicrobial, and antifungal properties. Here, we studied its anticancer, anti-inflammatory, and cytotoxic effects. Cells treated with BCP, in a dose-dependent manner, exhibited morphological changes, showed lower cell growth, underwent apoptosis and lost the ability to metastasis through the suppression of NF-Ò¡ B via PI3K/AKT signalling pathway. These results elucidate that the inhibition of NF-Ò¡ B and PI3K/AKT is one of the most important mechanism by which BCP suppresses cancer cell proliferation and enhances apoptosis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Estresse Oxidativo
/
Sesquiterpenos Policíclicos
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article