Monoclonal B-cell lymphocytosis.
Best Pract Res Clin Haematol
; 32(3): 229-238, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31585623
ABSTRACT
Flow cytometry diagnostic practices can detect very low levels of clonal B cells in the peripheral blood. In the absence of clinical symptoms, cytopenia or organomegaly, the small clones may correspond to monoclonal B-cell leukemia (MBL) diagnosis. Most MBLs harbor a chronic lymphocytic leukemia (CLL) phenotype (e.g., CD5+, CD23+) and are referred to as CLL-type MBL. The two other types are atypical CLL-type MBL and non-CLL-type MBL. In addition to the phenotypical classification, the clonal B count is a major issue because of the impact on the prognosis and the risk of progression in CLL. It allows for the discrimination of two distinct types high-count (HC) MBL and low-count (LC)-MBL based on a cutoff value of 0.5â¯×â¯109/L clonal B cells. LC MBL appears to be very stable over time and is probably related to immunosenescence. Conversely, HC MBL could be a premalignant state before the occurrence of CLL.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Linfócitos B
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Leucemia Linfocítica Crônica de Células B
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Linfocitose
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article