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In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Chaturvedi, Anuhar; Goparaju, Ramya; Gupta, Charu; Weder, Julia; Klünemann, Thomas; Araujo Cruz, Michelle Maria; Kloos, Arnold; Goerlich, Kerstin; Schottmann, Renate; Othman, Basem; Struys, Eduard A; Bähre, Heike; Grote-Koska, Denis; Brand, Korbinian; Ganser, Arnold; Preller, Matthias; Heuser, Michael.
Afiliação
  • Chaturvedi A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Goparaju R; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Gupta C; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Weder J; Institute for Biophysical Chemistry, Hannover Medical School, Hannover and Centre for Structural Systems Biology, Hamburg, Germany.
  • Klünemann T; Institute for Biophysical Chemistry, Hannover Medical School, Hannover and Centre for Structural Systems Biology, Hamburg, Germany.
  • Araujo Cruz MM; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Kloos A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Goerlich K; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Schottmann R; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Othman B; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Struys EA; Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands.
  • Bähre H; Research Core Unit Metabolomics, Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
  • Grote-Koska D; Institute of Clinical Chemistry, Hannover Medical School, Hannover, Germany.
  • Brand K; Institute of Clinical Chemistry, Hannover Medical School, Hannover, Germany.
  • Ganser A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Preller M; Institute for Biophysical Chemistry, Hannover Medical School, Hannover and Centre for Structural Systems Biology, Hamburg, Germany. preller.matthias@mh-hannover.de.
  • Heuser M; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. heuser.michael@mh-hannover.de.
Leukemia ; 34(2): 416-426, 2020 02.
Article em En | MEDLINE | ID: mdl-31586149
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sítios de Ligação / Inibidores Enzimáticos / Isocitrato Desidrogenase / Mutação Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sítios de Ligação / Inibidores Enzimáticos / Isocitrato Desidrogenase / Mutação Idioma: En Ano de publicação: 2020 Tipo de documento: Article