Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury.

Huang, Zhenlin; Zhao, Qing; Chen, Minwei; Zhang, Jingnan; Ji, Lili

Huang, Zhenlin; Zhao, Qing; Chen, Minwei; Zhang, Jingnan; Ji, Lili.

Afiliação

Huang Z; The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine,
Zhao Q; The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine,
Chen M; The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine,
Zhang J; The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine,
Ji L; The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine,

Toxicology ; 428: 152307, 2019 12 01.

Article em En | MEDLINE | ID: mdl-31589899

Assuntos

Anti-Inflamatórios/uso terapêutico; Chaperonina 60/metabolismo; Flavanonas/uso terapêutico; Glucosídeos/uso terapêutico; Hepatopatia Veno-Oclusiva/tratamento farmacológico; Trifosfato de Adenosina/metabolismo; Animais; Anti-Inflamatórios/farmacologia; Flavanonas/farmacologia; Glucosídeos/farmacologia; Hepatopatia Veno-Oclusiva/induzido quimicamente; Hepatopatia Veno-Oclusiva/metabolismo; Hepatopatia Veno-Oclusiva/patologia; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Masculino; Camundongos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Monocrotalina; Células RAW 264.7; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

HSOS; HSP60; Liquiritigenin; Liquiritin; Lon; NFκB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatopatia Veno-Oclusiva / Chaperonina 60 / Flavanonas / Glucosídeos / Anti-Inflamatórios Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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