Quantitative analysis of underivatized 17 ß-estradiol using a high-throughput LC-MS/MS assay - Application to support a pharmacokinetic study in ovariectomized guinea pigs.

Gandhi, Adarsh; Matta, Murali K; Stewart, Sharron; Chockalingam, Ashok; Knapton, Alan; Rouse, Rodney; Wu, Wendy; Patel, Vikram

Gandhi, Adarsh; Matta, Murali K; Stewart, Sharron; Chockalingam, Ashok; Knapton, Alan; Rouse, Rodney; Wu, Wendy; Patel, Vikram.

Afiliação

Gandhi A; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States. Electronic address: adarsh.gandhi@fda.hhs.gov.
Matta MK; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.
Stewart S; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.
Chockalingam A; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.
Knapton A; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.
Rouse R; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.
Wu W; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.
Patel V; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drugs Evaluation and Research, US Food and Drug Administration, United States.

J Pharm Biomed Anal ; 178: 112897, 2020 Jan 30.

Article em En | MEDLINE | ID: mdl-31593865

Assuntos

Cromatografia Líquida/métodos; Estradiol/farmacocinética; Espectrometria de Massas em Tandem/métodos; Animais; Área Sob a Curva; Relação Dose-Resposta a Droga; Estradiol/administração & dosagem; Feminino; Cobaias; Meia-Vida; Ensaios de Triagem em Larga Escala; Extração Líquido-Líquido; Ovariectomia

Palavras-chave

17 ß-estradiol; High-throughput; Liquid-liquid extraction; Mass spectrometry; Pharmacokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Estradiol / Espectrometria de Massas em Tandem Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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