Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: Population pharmacokinetic modelling and simulations for improved dosing schemes.

Vu, Dinh H; Nguyen, Duy A; Delattre, Isabelle K; Ho, Trong T; Do, Hong G; Pham, Hong N; Dao, Xuan C; Tran, Nhan T; Nguyen, Gia B; Van Bambeke, Françoise; Tulkens, Paul M; Nguyen, Hoang A

Vu, Dinh H; Nguyen, Duy A; Delattre, Isabelle K; Ho, Trong T; Do, Hong G; Pham, Hong N; Dao, Xuan C; Tran, Nhan T; Nguyen, Gia B; Van Bambeke, Françoise; Tulkens, Paul M; Nguyen, Hoang A.

Afiliação

Vu DH; National Drug Information and Adverse Drug Reaction Monitoring Center, Hanoi University of Pharmacy, Hanoi, Vietnam. Electronic address: vudinhhoa@gmail.com.
Nguyen DA; National Drug Information and Adverse Drug Reaction Monitoring Center, Hanoi University of Pharmacy, Hanoi, Vietnam.
Delattre IK; Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Ho TT; National Drug Information and Adverse Drug Reaction Monitoring Center, Hanoi University of Pharmacy, Hanoi, Vietnam.
Do HG; Department of Pharmacy, Bach Mai Hospital, Hanoi, Vietnam.
Pham HN; Department of Microbiology, Bach Mai Hospital, Hanoi, Vietnam.
Dao XC; Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam.
Tran NT; Department of Pharmacy, Bach Mai Hospital, Hanoi, Vietnam.
Nguyen GB; Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam.
Van Bambeke F; Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Tulkens PM; Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Nguyen HA; National Drug Information and Adverse Drug Reaction Monitoring Center, Hanoi University of Pharmacy, Hanoi, Vietnam.

Int J Antimicrob Agents ; 54(6): 702-708, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31600554

Assuntos

Estado Terminal; Modelos Biológicos; Vancomicina/administração & dosagem; Vancomicina/farmacocinética; Adulto; Idoso; Antibacterianos/administração & dosagem; Antibacterianos/farmacocinética; Simulação por Computador; Relação Dose-Resposta a Droga; Esquema de Medicação; Monitoramento de Medicamentos; Enterococcus/efeitos dos fármacos; Feminino; Humanos; Masculino; Testes de Sensibilidade Microbiana; Pessoa de Meia-Idade; Método de Monte Carlo; Staphylococcus aureus/efeitos dos fármacos

Palavras-chave

Continuous infusion; Critically ill; Loading dose; Maintenance dose; Vancomycin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vancomicina / Estado Terminal / Modelos Biológicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vancomicina / Estado Terminal / Modelos Biológicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article