Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.

Kreuzaler, Peter; Clarke, Matthew A; Brown, Elizabeth J; Wilson, Catherine H; Kortlever, Roderik M; Piterman, Nir; Littlewood, Trevor; Evan, Gerard I; Fisher, Jasmin

Kreuzaler, Peter; Clarke, Matthew A; Brown, Elizabeth J; Wilson, Catherine H; Kortlever, Roderik M; Piterman, Nir; Littlewood, Trevor; Evan, Gerard I; Fisher, Jasmin.

Afiliação

Kreuzaler P; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Clarke MA; Oncogenes and Tumour Metabolism Lab, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Brown EJ; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Wilson CH; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Kortlever RM; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Piterman N; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Littlewood T; Department of Computer Science and Engineering, University of Gothenburg, SE-41296 Gothenburg, Sweden.
Evan GI; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Fisher J; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom; gie20@cam.ac.uk jf416@cam.ac.uk.

Proc Natl Acad Sci U S A ; 116(44): 22399-22408, 2019 10 29.

Article em En | MEDLINE | ID: mdl-31611367

Assuntos

Heterogeneidade Genética; Neoplasias Mamárias Experimentais/genética; Modelos Teóricos; Proteínas Proto-Oncogênicas c-myc/genética; Animais; Resistencia a Medicamentos Antineoplásicos; Feminino; Neoplasias Mamárias Experimentais/tratamento farmacológico; Neoplasias Mamárias Experimentais/metabolismo; Camundongos; Proteínas Proto-Oncogênicas c-myc/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Via de Sinalização Wnt; Proteínas ras/genética; Proteínas ras/metabolismo

Palavras-chave

Myc; breast cancer; cancer heterogeneity; computational modeling; oncogenic signaling

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-myc / Heterogeneidade Genética / Neoplasias Mamárias Experimentais / Modelos Teóricos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google