Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice.
Sci Rep
; 9(1): 14848, 2019 10 16.
Article
em En
| MEDLINE
| ID: mdl-31619733
ABSTRACT
Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
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Enfisema Pulmonar
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Poluição por Fumaça de Tabaco
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DNA
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Receptor de Interferon alfa e beta
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Proteínas de Membrana
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Nucleotidiltransferases
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article