[Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 33(10): 954-957, 2019 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-31623042
ABSTRACT
Objective:
The aim of this study is to investigate the effects of rhodiola rosea on oxidative stress, anxiety and depression in patients with OSA.Method:
Ninety patients with moderate and severe OSA patients with negative emotions diagnosed by PSG, self-rating depression scale ï¼SDSï¼ and self-rating anxiety scale ï¼SASï¼ were selected from the respiratory department of our hospital from February 2015 to February 2018. According to the random number table method, the patients were randomly divided into non-invasive ventilator group, rhodiola rosea+non-invasive ventilator group and rhodiola rosea group, with 30 cases in each group. Patients in the non-invasive ventilator group were treated with continuous positive airway pressure ï¼CPAPï¼ for 3 months, and those in the rhodiola rosea+non-invasive ventilator group were treated with oral rhodiola capsules for 3 months on the basis of CPAP, and those in the rhodiola rosea treatment group were treated with pure oral rhodiola capsules for 3 months. The changes of SDS and SAS before and after the three groups were compared, and the changes of serum SOD and MDA were detected by immunoenzyme-linked adsorption for comparative analysis.Result:
There were no significant differences in SDS and SAS scores between the three groups ï¼P>0.05ï¼. SDS and SAS scores of patients in the rhodiola rosea+non-invasive ventilator group decreased after treatment ï¼P<0.05ï¼ compared with those in the non-invasive ventilator group. SDS and SAS scores of patients in the rhodiola treatment group increased after treatment ï¼P<0.05ï¼. Compared with those in the rhodiola treatment group, SDS and SAS scores of patients in the rhodiola+non-invasive breathing group decreased after treatment ï¼P<0.05ï¼. Three group patients were no significant difference in serum SOD and malondialdehyde ï¼MDAï¼ before treatment ï¼P>0.05ï¼. Compared with before treatment, serum SOD level were all increased and MDA level were all decreased in the three groups after treatment ï¼P<0.05ï¼. Compared with noninvasive breathing unit after treatment, rhodiola+noninvasive breathing unit after treatment in patients with elevated levels of serum SOD, MDA level decreased ï¼P<0.05ï¼, and for the treatment group after treatment in patients with serum SOD levels drop, the MDA levels ï¼P<0.05ï¼, and the after rhodiola rosea treatment group compared, rhodiola+noninvasive breathing unit after treatment in patients with elevated levels of serum SOD, MDA level decreased ï¼P<0.05ï¼.Conclusion:
Rhodiola may improve the negative emotions such as anxiety and depression by inhibiting oxygen free radicals and lipid peroxidation in patients with OSA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
/
Extratos Vegetais
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Apneia Obstrutiva do Sono
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Rhodiola
Idioma:
Zh
Ano de publicação:
2019
Tipo de documento:
Article