An Activatable NIR-II Nanoprobe for Inâ
Vivo Early Real-Time Diagnosis of Traumatic Brain Injury.
Angew Chem Int Ed Engl
; 59(1): 247-252, 2020 01 02.
Article
em En
| MEDLINE
| ID: mdl-31626380
ABSTRACT
Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis and real-time feedback on the pathological process. Herein, a targeted activatable fluorescent nanoprobe (V&A@Ag2 S) in the second near-infrared window (NIR-II) is presented for inâ
vivo optical imaging of TBI. Initially, the fluorescence of V&A@Ag2 S is turned off owing to energy transfer from Ag2 S to the A1094 chromophore. Upon intravenous injection, V&A@Ag2 S quickly accumulates in the inflamed vascular endothelium of TBI based on VCAM1-mediated endocytosis, after which the nanoprobe achieves rapid recovery of the NIR-II fluorescence of Ag2 S quantum dots (QDs) owing to the bleaching of A1094 by the prodromal biomarker of TBI, peroxynitrite (ONOO- ). The nanoprobe offers high specificity, rapid response, and high sensitivity toward ONOO- , providing a convenient approach for inâ
vivo early real-time assessment of TBI.
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MEDLINE
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Imagem Óptica
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Lesões Encefálicas Traumáticas
Idioma:
En
Ano de publicação:
2020
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Article