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Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells.
Pathmanathan, Siva Gowri; Lawley, Blair; McConnell, Michelle; Baird, Margaret A; Tannock, Gerald W.
Afiliação
  • Pathmanathan SG; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; Department of Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia (USIM), Kuala Lumpur, Malaysia. Electronic address: gowri@usim.edu.my.
  • Lawley B; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
  • McConnell M; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
  • Baird MA; Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
  • Tannock GW; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Anaerobe ; 61: 102112, 2020 Feb.
Article em En | MEDLINE | ID: mdl-31629806
ABSTRACT
Immuno-modulatory effects of infant gut bacteria were tested on poly(IC) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(IC)-induced inflammatory genes. Modulation of basal level and poly(IC)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bactérias / Transcrição Gênica / Regulação da Expressão Gênica / Microbioma Gastrointestinal Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bactérias / Transcrição Gênica / Regulação da Expressão Gênica / Microbioma Gastrointestinal Idioma: En Ano de publicação: 2020 Tipo de documento: Article