Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn's disease patients.

Zhu, Xia; Chao, Kang; Li, Miao; Xie, Wen; Zheng, Hong; Zhang, Jin-Xin; Hu, Pin-Jin; Huang, Min; Gao, Xiang; Wang, Xue-Ding

Zhu, Xia; Chao, Kang; Li, Miao; Xie, Wen; Zheng, Hong; Zhang, Jin-Xin; Hu, Pin-Jin; Huang, Min; Gao, Xiang; Wang, Xue-Ding.

Afiliação

Zhu X; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Chao K; Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Li M; Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Xie W; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Zheng H; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Zhang JX; School of Public Health, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Hu PJ; Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Huang M; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Gao X; Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Wang XD; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China. wangxd@mail.sysu.edu.cn.

World J Gastroenterol ; 25(38): 5850-5861, 2019 Oct 14.

Article em En | MEDLINE | ID: mdl-31636477

Assuntos

Doença de Crohn/tratamento farmacológico; Nucleotídeos de Guanina/sangue; Imunossupressores/efeitos adversos; Leucopenia/diagnóstico; Mercaptopurina/efeitos adversos; Pirofosfatases/genética; Tionucleotídeos/sangue; Adolescente; Adulto; Idoso; Povo Asiático/genética; Variação Biológica da População/genética; Biomarcadores/sangue; Criança; Doença de Crohn/sangue; Doença de Crohn/imunologia; Feminino; Humanos; Leucopenia/induzido quimicamente; Masculino; Pessoa de Meia-Idade; Polimorfismo de Nucleotídeo Único; Valor Preditivo dos Testes; Prognóstico; Valores de Referência; Estudos Retrospectivos; Adulto Jovem

Palavras-chave

Crohn's disease; Nucleoside diphosphate-linked moiety X-type motif 15; Thioguanine nucleotide levels; Thiopurine-induced leukopenia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirofosfatases / Tionucleotídeos / Doença de Crohn / Nucleotídeos de Guanina / Imunossupressores / Leucopenia / Mercaptopurina Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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