Cyclobutastellettolides A and B, C19 Norterpenoids from a Stelletta sp. Marine Sponge.
J Nat Prod
; 82(11): 3196-3200, 2019 11 22.
Article
em En
| MEDLINE
| ID: mdl-31646862
ABSTRACT
Two novel C19 terpenoids (1, 2) with an unprecedented carbon skeleton (A) were isolated from a Stelletta sp. sponge collected from Vietnamese waters. Their structures and absolute configurations were established by extensive NMR, MS, and ECD analyses together with quantum chemical modeling and biogenetic considerations. The probable pathways of biogenesis of 1 and 2 from isomalabaricane triterpenoids are discussed. Compounds 1 and 2 significantly increase the production of reactive oxygen species in murine peritoneal macrophages.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Terpenos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article