Iridoid glucosides and triterpene acids from Phlomis linearifolia, growing in Uzbekistan and its hepatoprotective activity.

ABSTRACT

A number of iridoids and triterpene acids, such as pulchelloside, sesamoside, shanshiside methyl ester, barlerin, gypsogenin acid and acetate of gypsogenic acid were isolated from the aerial part of Phlomis linearifolia and their structures were confirmed by NMR, mass and IR spectroscopy. In addition, the hepatoprotective potential of iridoid fraction from P. linearifolia aerial parts was tested against CCl4 induced fibrosis in rats. The iridoid fraction not only prevented the manifestation of the hepatotoxic effect of CCl4, but rather quickly eliminated the effects of developing intoxication. The hepatoprotective activity of the SI was confirmed to be effective and exceeds knows drug carsil.Supplemental data for this article can be accessed at https//doi.org/10.1080/14786419.2019.1677650.