Polymeric precipitation inhibitor as an effective trigger to convert supersaturated into supersaturable state in vivo.
Ther Deliv
; 10(9): 599-608, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31646935
ABSTRACT
The supersaturated state of the drug in vivo is thermodynamically unstable resulting in a delayed response and reduced efficacy. The use of polymeric precipitation inhibitor (PPI) has been demonstrated as an effective trigger for the conversion of supersaturated state to supersaturable state for improving solubilization, thermodynamic maintenance of drug concentration and oral absorption of poorly water-soluble compounds. PPI retards drug precipitation and provides a kinetically stabilized supersaturation state for an extended period in gastric and intestinal fluids. However, the selection of appropriate PPI and understanding its mechanism is a challenge for formulating a stable pharmaceutical formulation. The present review is aimed at understanding the intricacies of selecting PPIs and their applications in pharmaceutical formulations.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article