Vasodilatory effect and structural-activity relationship of a group of iridoid glucosides from Phlomis likiangensis.

Hu, Li-Jiao; Qi, Yan-Yan; Chen, Ke-Jin; Yang, Cui; Wu, Hai-Yan; Li, Gan-Peng

Hu, Li-Jiao; Qi, Yan-Yan; Chen, Ke-Jin; Yang, Cui; Wu, Hai-Yan; Li, Gan-Peng.

Afiliação

Hu LJ; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China.
Qi YY; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China.
Chen KJ; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China.
Yang C; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China.
Wu HY; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China. Electronic address: hywu82@126.com.
Li GP; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China; School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China. Electronic address: ganpeng_li@163.com.

Fitoterapia ; 139: 104365, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31647954

Assuntos

Glucosídeos Iridoides/farmacologia; Phlomis/química; Vasodilatadores/farmacologia; Animais; Aorta/efeitos dos fármacos; Células Cultivadas; China; Células Endoteliais/efeitos dos fármacos; Técnicas In Vitro; Glucosídeos Iridoides/química; Masculino; Estrutura Molecular; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo III/metabolismo; Plantas Medicinais/química; Ratos; Ratos Sprague-Dawley; Rizoma/química; Relação Estrutura-Atividade; Vasodilatação; Vasodilatadores/química

Palavras-chave

Iridoid glucosides; Mechanisms; Phlomis likiangensis; Structure-activity relationship; Vasodilatation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vasodilatadores / Phlomis / Glucosídeos Iridoides Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vasodilatadores / Phlomis / Glucosídeos Iridoides Idioma: En Ano de publicação: 2019 Tipo de documento: Article