Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate.

Sun, Hong; Ko, Tzu-Ping; Liu, Wenting; Liu, Weidong; Zheng, Yingying; Chen, Chun-Chi; Guo, Rey-Ting

Sun, Hong; Ko, Tzu-Ping; Liu, Wenting; Liu, Weidong; Zheng, Yingying; Chen, Chun-Chi; Guo, Rey-Ting.

Afiliação

Sun H; University of Chinese Academy of Sciences, Beijing, 100049, China; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Ko TP; Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.
Liu W; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Liu W; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Zheng Y; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Chen CC; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address: ccckate0722@gmail.com.
Guo RT; University of Chinese Academy of Sciences, Beijing, 100049, China; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Re

Biochem Biophys Res Commun ; 521(1): 31-36, 2020 01 01.

Article em En | MEDLINE | ID: mdl-31653344

Assuntos

Antibacterianos/biossíntese; Oligossacarídeos/biossíntese; UDPglucose 4-Epimerase/metabolismo; Antibacterianos/química; Cristalografia por Raios X; Modelos Moleculares; Oligossacarídeos/química; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Streptomyces/enzimologia; Especificidade por Substrato; UDPglucose 4-Epimerase/química; UDPglucose 4-Epimerase/genética

Palavras-chave

Galacturonic acid; Moenomycin; NAD; Rossmann fold; X-ray crystallography

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / UDPglucose 4-Epimerase / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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