High-energy visible light at ambient doses and intensities induces oxidative stress of skin-Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo.
Photodermatol Photoimmunol Photomed
; 36(2): 135-144, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31661571
ABSTRACT
BACKGROUND:
Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products.METHODS:
We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA).RESULTS:
Visible spectrum of 400-500 nm dose-dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm2 ). A pretreatment for 24 hours with 1 µmol/L LicA reduced ROS formation to the level of unirradiated cells while UV filters alone were ineffective, even at SPF50+. In vivo, topical treatment with a LicA-containing SPF50 + formulation significantly prevented the depletion of intradermal carotenoids by VIS irradiation while SPF50 + control did not protect.CONCLUSION:
LicA may be a useful additive antioxidant for sunscreens.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Luz Solar
/
Protetores Solares
/
Estresse Oxidativo
/
Derme
/
Fator 2 Relacionado a NF-E2
/
Fibroblastos
/
Antioxidantes
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article