Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.

Kalinin, Sergey; Meares, Gordon P; Lin, Shao Xia; Pietruczyk, Elizabeth A; Saher, Gesine; Spieth, Lena; Nave, Klaus-Armin; Boullerne, Anne I; Lutz, Sarah E; Benveniste, Etty N; Feinstein, Douglas L

Kalinin, Sergey; Meares, Gordon P; Lin, Shao Xia; Pietruczyk, Elizabeth A; Saher, Gesine; Spieth, Lena; Nave, Klaus-Armin; Boullerne, Anne I; Lutz, Sarah E; Benveniste, Etty N; Feinstein, Douglas L.

Afiliação

Kalinin S; Department of Anesthesiology, University of Illinois, Chicago, Illinois.
Meares GP; Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia.
Lin SX; Department of Anesthesiology, University of Illinois, Chicago, Illinois.
Pietruczyk EA; Department of Anatomy and Cell Biology, University of Illinois, Chicago, Illinois.
Saher G; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany.
Spieth L; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany.
Nave KA; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany.
Boullerne AI; Department of Anesthesiology, University of Illinois, Chicago, Illinois.
Lutz SE; Department of Anatomy and Cell Biology, University of Illinois, Chicago, Illinois.
Benveniste EN; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.
Feinstein DL; Department of Anesthesiology, University of Illinois, Chicago, Illinois.

Glia ; 68(3): 600-616, 2020 03.

Article em En | MEDLINE | ID: mdl-31664743

Assuntos

Astrócitos/metabolismo; Esclerose Múltipla/metabolismo; Bainha de Mielina/metabolismo; Proteínas Serina-Treonina Quinases/deficiência; Proteínas Quinases Ativadas por AMP; Animais; Diferenciação Celular/genética; Sobrevivência Celular/fisiologia; Modelos Animais de Doenças; Encefalomielite Autoimune Experimental/genética; Encefalomielite Autoimune Experimental/patologia; Fígado/metabolismo; Camundongos Knockout; Esclerose Múltipla/genética; Medula Espinal/patologia

Palavras-chave

EAE; astrocyte; liver kinase B1; mitochondria; motor neuron; multiple sclerosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Proteínas Serina-Treonina Quinases / Esclerose Múltipla / Bainha de Mielina Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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