Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons.

Bao, Xiu-Qi; Wang, Lu; Yang, Han-Yu; Hou, Li-Yan; Wang, Qing-Shan; Zhang, Dan

Bao, Xiu-Qi; Wang, Lu; Yang, Han-Yu; Hou, Li-Yan; Wang, Qing-Shan; Zhang, Dan.

Afiliação

Bao XQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Xian Nong Tan Street, Beijing, 100050, China.
Wang L; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Xian Nong Tan Street, Beijing, 100050, China.
Yang HY; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Xian Nong Tan Street, Beijing, 100050, China.
Hou LY; Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Wang QS; Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China. Electronic address: wangq1998@aliyun.com.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Xian Nong Tan Street, Beijing, 100050, China. Electronic address: danzhang@imm.ac.cn.

Brain Res Bull ; 154: 32-42, 2020 01.

Article em En | MEDLINE | ID: mdl-31669104

Assuntos

Astrócitos/metabolismo; Neurônios Dopaminérgicos/metabolismo; Fator Neurotrófico Derivado de Linhagem de Célula Glial/metabolismo; Acrilamidas/efeitos adversos; Acrilamidas/farmacologia; Animais; Astrócitos/efeitos dos fármacos; Benzenoacetamidas/farmacologia; Ácidos Cafeicos/efeitos adversos; Ácidos Cafeicos/farmacologia; Modelos Animais de Doenças; Dopamina/metabolismo; Neurônios Dopaminérgicos/efeitos dos fármacos; Fator Neurotrófico Derivado de Linhagem de Célula Glial/fisiologia; Mesencéfalo/citologia; Neuroglia/metabolismo; Fármacos Neuroprotetores/metabolismo; Fármacos Neuroprotetores/farmacologia; Doença de Parkinson/metabolismo; Fenóis/farmacologia; Fosfatidilinositol 3-Quinases/metabolismo; Cultura Primária de Células/métodos; Ratos; Ratos Sprague-Dawley

Palavras-chave

Astroglia; CAMP-response element binding protein; Dopaminergic neuron; FLZ; Glial cell line-derived neurotrophic factor; Parkinson's disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Fator Neurotrófico Derivado de Linhagem de Célula Glial / Neurônios Dopaminérgicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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